Post Tagged with: "newdrugs"

Review of BRAF/MEK Combo NEJM data

0 / October 3, 2012 4:32 pm

eat results from multiple clinical trials treating advanced melanoma keep coming, as the NEJM publication from this GSK (Glaxo SmithKline)-sponsored trial recently affirmed. This trial was a Phase I-II trial of combination therapy for advanced melanoma harboring a v600 […]

Second Line Therapy with BRAF Inhibitor PLX4032/RG7204

Second Line Therapy with BRAF Inhibitor PLX4032/RG7204

0 / May 15, 2011 9:55 pm

as presented by Dr. Jeff Sosman from Vanderbilt. BRIM-2 trial: n=132 melanoma patients who had progressed on prior therapy and had V600E BRAF mutations. They were treated with RG7204 (previously PLX4032) at 960 mg BID. Primary endpoint was best […]

GSK BRAF Inhibitor With Early But Impressive Results

GSK BRAF Inhibitor With Early But Impressive Results

1 / May 15, 2011 9:52 pm

Presented by Rick Kefford, MD, from Melanoma Institute of Australia. This was a Phase I/II trial of this agent (colloquially called “436″) in melanoma. 112 patients were treated in a dose escalation construct, all with mutant BRAF melanomas. The […]

Ipilimumab at Plenary Session 2010

Ipilimumab at Plenary Session 2010

0 / May 15, 2011 9:39 pm

for the first time anybody can remember, a melanoma study was presented at the ASCO plenary. It was very exciting for me to see my good friend Steve O’Day from The Angeles Clinic standing in front of what is […]

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