Diphencyprone (DPCP) as Topical Agent to Treat Melanoma

This is an inexpensive topical therapy that appears to have some efficacy in regionally advanced cutanous melanoma. In small numbers of patients, there is a significant response rate. I don’t believe it is approved in the United States but I think it is approved for other, non-melanoma, therapies in Australia.

The presenter had a number of interesting photos that showed regression of advanced skin lesions. I believe the overall response rate was in the 60% range, although I may have missed the exact numbers.

Not clear to me where this compound is going in terms of development for melanoma treatment. It is so inexpensive that unfortunately there may never be industrial support for additional testing. However, the results are certainly interesting.

Eric D. Whitman, MD

Senior Editor



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